The Fellow on Call: The Heme/Onc Podcast Episode 104: Colorectal Cancer Series, Pt. 6 - Colorectal Cancer Pharmacology
May 29, 2024
Allison Schepers, a Clinical Pharmacist Specialist at the Rogel Cancer Center, shares her expertise in colorectal cancer pharmacology. She delves into essential drugs like capecitabine and oxaliplatin, discussing their management and side effects. Allison explores toxicity management, including uridine triacetate as an antidote for 5-FU toxicity. She also highlights the latest HER2 targeted treatments, emphasizing the importance of collaboration in patient care. Her insights are invaluable for navigating the complex landscape of colorectal cancer therapies.
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Continuous Infusion 5-FU Benefits
- Continuous infusion 5-FU regimens are better tolerated than bolus doses.
- They have less mucositis, diarrhea, and hematologic toxicity but are more effective.
Preventing Hand-Foot Syndrome
- Use non-scented or urea-based moisturizers twice daily during capecitabine treatment.
- Avoid heat and friction on hands and feet to prevent hand-foot syndrome.
Managing 5-FU Coronary Vasospasm
- Rechallenge 5-FU-induced coronary vasospasm with caution using premedication.
- Use nitrates and calcium channel blockers starting 24–48 hours before infusion.