229: The New GLP-1 Pill That Could Replace Injections

GLP-1s have dominated the headlines, but the next wave of compounds is already here, and they're changing the conversation on fat loss, performance, and longevity. In this episode, I break down the science behind four emerging therapies and why you need to know about them now.

We cover how Afoglipron, the first oral non-peptide GLP-1, removes the barrier of injections while delivering results on par with semaglutide. You'll hear why Teriparatide, originally used for osteoporosis, may reduce visceral fat and protect bone density at the same time. I also dive into Mazdutide, a dual GLP-1/glucagon agonist that suppresses appetite while boosting energy expenditure, and Tesofensine, a brain-targeting appetite suppressant with powerful effects on cravings.

I share what the latest clinical data shows, the benefits and risks for both general populations and athletes, and how these compounds could fit into the bigger picture of training, nutrition, and longevity.

This is a must-listen.

What's Discussed:

00:05 — Why GLP-1s have exploded and what's next beyond semaglutide

01:53 — Afoglipron: The first oral GLP-1 and why it's a game changer

07:16 — Teriparatide: Surprising fat loss potential in a bone health drug

10:29 — Mazdutide: The "eat less, burn more" dual agonist

13:17 — Tesofensine: Targeting food noise and cravings in the brain

16:20 — Are these drugs the future of fat loss, or a Pandora's box?

Thank you to our sponsors:

NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris

BiOptimizers - code KRIS10 for 10% off https://bioptimizers.com/

Timeline: My friends at Timeline are offering 20% off, just for my listeners. Head to timeline.com/GETHIN to get started.

LVLUP: Head over to LVLUPHealth.com and use code GETHIN at checkout to get 20% off.

Find more from Kris:

Website: https://www.krisgethin.com/

Instagram: @krisgethin

Youtube: https://www.youtube.com/krisgethin Unmatched Supplements: https://www.unmatchedsupps.com/