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The Ultimate Human with Gary Brecka

24. COMT Gene Mutation: How to Supplement For Better Sleep and Reduced Anxiety | Ultimate Human Short with Gary Brecka

Jan 4, 2024
Learn about the COMT gene mutation and its impact on the body, including neurotransmitter effects and estrogen metabolism. Discover personal struggles with sleep and overthinking. Explore the traits associated with the mutation, such as successful entrepreneurship and reliability. Understand the link between estrogen dominance and water retention. Dive into the effects of green tea and quercetin on sleep and anxiety. Find out about supplement options like methyl folate and Sam E.
22:58

Podcast summary created with Snipd AI

Quick takeaways

  • The COMT gene mutation can cause issues like racing thoughts at bedtime, perfectionism, and sensitivity to sounds and textures, which can be improved through specific supplements.
  • Individuals with the COMT gene mutation may possess mental characteristics like obsessiveness, perfectionism, and a detail-oriented nature, which can be advantageous in entrepreneurial roles but may also present challenges in traditional employment settings.

Deep dives

Understanding the C-O-M-T Gene Mutation

The podcast delves into the genetic mutation C-O-M-T and its impact on neurotransmitters and estrogen metabolism. The mutation downregulates catecholamines, fight-or-flight neurotransmitters that can lead to heightened states of anxiety and wakefulness. It also affects estrogen metabolism, potentially resulting in estrogen dominance and water retention. The hosts discuss personal experiences related to these symptoms, such as overthinking, obsessive-compulsive tendencies, and challenges with sleep. The importance of identifying and addressing this gene mutation through specific dietary changes and targeted supplements is emphasized.

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