Microdosing GLP1s Has Gone Mainstream | Quick + Dirty

EP. 201: On this quick-and-dirty solo episode, I'm diving into a brand-new article just published in Diabetes Care (March 2025, Vol. 48):

"One Size Does Not Fit All: Understanding Microdosing Semaglutide for Diabetes and Multi-Dose Pens."

This opinion piece by respected endocrinologists signals a massive shift in the conversation—one I’ve been screaming from the rooftops for over a year. While I’m not claiming credit (ok maybe a little), I am thrilled to see microdosing GLP-1s being acknowledged by mainstream medicine… even if they’re still getting a lot of it, well, OFF.

Let’s be clear: microdosing  was NEVER meant to be a weight loss strategy, even thought that’s what everyone seems to think it’s for. And if you’re NOT using these drugs without a full metabolic support plan—protein, lifting, hormones, insulin sensitivity—you’re setting yourself (or your patients) up to fail.

Topics Discussed: 

• What the pen-click method is and why it's a game-changer
• Why splitting up a full dose is not microdosing (despite what TikTok tells you)
• The difference between low-dosing, standard dosing, and true microdosing
• Why microdosing isn’t a long-term solution for weight loss or type 2 diabetes
• How this concept can support tolerability, access, and personalized care
• Why most “microdosing” marketing is just sloppy semantics
• The real clinical rationale behind true microdosing
• How to use GLP-1s intelligently as part of a broader metabolic protocol

I break it all down in this episode, and if you want to go deeper, grab my free 4-part video series at drtyna.com/ozempicuncovered — it’ll walk you straight into the most comprehensive GLP-1 course available for clinicians and smart self-healers alike.

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On This Episode We Cover:

• 00:00:00 - Introduction & Milestone
• 00:02:45 - Ozempic: Weight Loss & Dosing
• 00:10:28 - Semaglutide Research Highlights
• 00:14:12 - Pen-Click Microdosing Method
• 00:16:06 - GLP-1s in Treatment Plans

Further Listening: 

• GLP1s Uncovered FREE 4 Part Video Series 

Show Links: 

• One Size Does Not Fit All: Understanding Microdosing Semaglutide for Diabetes in Multidose Pens

Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.