The Human Upgrade: Biohacking for Longevity & Performance

Urolithin A: The Miracle Compound - Dr. Dominic Denk : 1119

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Dec 28, 2023

In this conversation, Dr. Dominic Denk, a physician specializing in aging and cancer research at University Hospital Frankfurt, illuminates the groundbreaking benefits of Urolithin A. Find out how this powerful compound supports mitochondrial health, boosts muscle strength, and enhances cognitive function. Dr. Denk dives into its role in cancer prevention and autoimmunity while discussing the differences in healthcare approaches between the U.S. and Germany. Uncover the potential of Urolithin A to revolutionize your wellness routine and longevity.

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ANECDOTE

German Lesson

Dave Asprey's grandfather taught him a German phrase, "du bist ein Eisel," meaning "you are a donkey."
Asprey, thinking it meant a different kind of "ass," asked his German teacher, who confirmed its meaning.

INSIGHT

Urolithin A Production

Urolithin A is a postbiotic produced by gut bacteria from foods like pomegranates, berries, and nuts.
Most people lack the gut bacteria to produce sufficient Urolithin A, especially as they age.

INSIGHT

Dietary Urolithin A Challenges

Eating enough walnuts for Urolithin A introduces excessive omega-6 fats.
Similarly, high raspberry consumption can lead to oxalic acid issues, making supplementation a practical solution.

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Get ready for this important download on a fascinating biohacking compound you haven’t heard me talk about before: Urolithin A. It’s a postbiotic that supports the mitochondria, and it’s backed by impressive studies on longevity, anti-cancer effects, cognitive function, and muscle strength. In fact, this compound has earned a place in my permanent stack—which you know isn’t easy to pull off.

Today, I chat with Dr. Dominic Denk, who’s done some of the original research on Urolithin A and the company that makes it, Timeline Nutrition powered by Mitopure. Dr. Denk works as a physician in the Department of Internal Medicine at University Hospital Frankfurt.

Dr. Denk breaks down what Urolithin A is and how it impacts aging and cancer prevention—answering questions on when, how, and why to take Mitopure—before we delve into the powers of mitochondria, how to have more energy production in your cells, and the relationship between energy production and cancer.

We also talk T cells, autoimmunity, and inflammation. Plus, we get into the differences in healthcare and pharmaceutical overreach in the U.S. and Germany. Tune in to uncover the latest life-changing compound—and find out what it will do for your heaviest lift in the gym, your cognition before your next big meeting, and to reverse aging over time.

(00:03:31) Understanding Urolithin A

(00:08:43) Genetic vs. Mitochondrial Cancer

(00:14:48) Getting to the Root of Autoimmunity

(00:21:19) Strong Evidence on Muscle Strength

(00:23:59) Does Cancer Hate Americans?

(00:27:59) Why Do We Age?

(00:31:35) The Best Studied Compound You’re Not Taking

(00:33:02) Talking T Cells

(00:36:22) Healthcare in Germany vs. The U.S.

(00:43:31) Urolithin A & Hot/Cold Therapies

(00:45:55) Tripling Down on mTOR

(00:52:05) Are There Downsides to Urolithin A?