Degrees of Health

Dr Dom D'Agostino | Augmenting Cancer Outcomes: Ketogenic Diets, Caloric Restriction & Hyperbaric Oxygen Therapy

Oct 15, 2024

Join Dr. Dom D'Agostino, a researcher and professor specializing in metabolic therapies for cancer, as he dives into innovative approaches to augment cancer outcomes. He discusses the therapeutic benefits of ketogenic diets and caloric restriction in slowing tumor growth and managing seizures. Dr. D'Agostino also highlights the synergy of hyperbaric oxygen therapy with traditional treatments and the role of fasting. Discover how mitochondrial health influences cancer development and the exciting potential of dietary interventions in enhancing standard care.

01:17:48

Creator website

Episode guests

Dom D'Agostino

AI Summary

AI Chapters

Episode notes

Podcast summary created with Snipd AI

Quick takeaways

Dr. Dom D'Agostino emphasizes that achieving a specific Glucose Ketone Index (GKI) is crucial for optimizing metabolic therapy in glioblastoma treatment.

The podcast highlights the potential of integrating non-toxic therapies like hyperbaric oxygen and metformin to enhance cancer treatment efficacy and reduce side effects.

Lifestyle modifications, particularly dietary changes and regular exercise, are vital in lowering cancer risk and improving overall health outcomes.

Deep dives

Metabolic Approach for Glioblastoma Treatment

For glioblastoma, a metabolic therapy approach is recommended, focusing on achieving a Glucose Ketone Index (GKI) between one and four. This involves lowering glucose levels while increasing ketones, which is associated with improved outcomes in animal models. Surgery may be an option for operable tumors, but instead of conventional treatments like chemotherapy and radiation, metabolic therapies should be prioritized. Additionally, therapies such as hyperbaric oxygen therapy and certain drugs like metformin and melatonin can further support treatment and help manage associated symptoms like seizures.

Intro

3min

Metabolic Approaches in Cancer Care

23min

Healing Through Diet: Fasting and Keto in Cancer Care

16min

Understanding PET Scans: The Role of Glucose Metabolism in Cancer Detection

2min

Exploring Red Light Therapy for Cancer Care

5min

Insights on Red Light Therapy and Glucose Monitoring

6min

Cognitive Benefits of Ketosis

14min

Mastering Goal-Setting for Wellness

10min

This podcast episode features an in-depth conversation on metabolic therapies and their potential in cancer treatment, particularly focused on glioblastoma and other glycolytic cancers. Our guest, Dr Dom D'Agostino, a researcher and professor with a diverse background in neuroscience, molecular pharmacology, nutrition and physiology, has a particular interest in metabolic therapies. Dr Dom shares how manipulating the body’s metabolism through the glucose ketone index (GKI), therapeutic ketogenic diets, and redox therapies can improve cancer outcomes by reducing tumour growth and enhancing standard treatments like chemotherapy and radiation. We also explore the synergies of non-toxic therapies such as hyperbaric oxygen, metformin, and IV vitamin C, and how these could potentially reduce the side effects and overall outcomes of cancer treatment.

We cover:

🩺 Standard cancer care with and without metabolic interventions

💊 Managing seizures with ketogenic therapies - a superior alternative to anti-seizure drugs

🍽 The power of fasting and the importance of protein intake in chemotherapy and cancer augmentation

🔥 Why certain cancers are more susceptible to metabolic-based therapies

🔬 How overall mitochondrial health dictates cancer cell transformation

Dom also touches on the fundamental relationship between liver health and cancer growth and metabolic strategies to prevent cancer. If you're interested in the intersection of nutrition and cancer or wondering how far we are from keto becoming part of standard care, this is a must-listen episode.

Find Dom:

Website

Metabolic Health Summit

Metabolic Health Summit YouTube

Mentioned in this episode:

Cancer cases attributable to potentially modifiable risk factors

Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

Ketones inhibit mitochondrial production of reactive oxygen species

The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival

Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer

Metabolic management of glioblastoma ...with a restricted ketogenic diet

Clinical trials in progress