Bloody Minded Episode 30 - Schnitzler’s List | Other Paraprotein Associated Diagnoses
Dec 31, 2024
Delve into the intriguing realm of paraproteins beyond myeloma. Discover rare conditions like Schnitzler's syndrome, POEMS syndrome, and cold agglutinin disease that challenge even seasoned healthcare professionals. The hosts explore the complexities of B-cell lymphomas and the relationship between paraproteins and malignancies. With a dash of humor, they dissect evolving medical acronyms and the diagnostic hurdles they present. Get ready to rethink what you know about unexplained health issues!
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MGUS Diagnosis Is of Exclusion
- MGUS is often diagnosed as a diagnosis of exclusion without extensive further investigation.
- Not checking deeper problems means we might miss paraprotein-related organ damage or disease.
Lymphomas Often Make Paraproteins
- Many B-cell lymphomas can produce paraproteins, especially IgM types.
- Lymphoplasmacytic lymphoma, associated with Waldenström's macroglobulinemia, is the most important lymphoma linked to paraproteins.
Understanding POEMS Syndrome Criteria
- POEMS syndrome requires polyneuropathy and monoclonal plasma cell disorder plus specific major and minor criteria.
- It features sclerotic bone lesions, organomegaly, skin changes, and unique endocrinopathies unlike typical diabetes.