The Dr. Hyman Show

Is Brain Inflammation The Cause of Depression, Dementia, ADD, And Autism? A Functional Medicine Approach To Neuroinflammation with Dr. Todd LePine

May 24, 2021
Dr. Todd LePine, a board-certified internist with expertise in integrative functional medicine, discusses the often-overlooked connection between brain inflammation and mental health disorders like depression and Alzheimer's. He argues that many conditions share underlying factors, challenging conventional medical views. The conversation highlights the critical roles of glial cells, gut health, and quinolinic acid in neuroinflammation. Dr. LePine advocates for holistic treatment approaches to restore mental and physical well-being by addressing root causes.
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INSIGHT

Glial Cells and Neuroinflammation

  • The brain's glial cells, not just neurons, are crucial in neuroinflammation.
  • Microglial cells, the brain's immune system, activate under threat, causing problems like depression.
ANECDOTE

PANDAS and Strep Infections

  • PANDAS, a pediatric autoimmune disorder, demonstrates the link between strep infections and brain inflammation.
  • Molecular mimicry in strep infections can lead to antibodies attacking the brain, causing neurological issues.
INSIGHT

Brain Inflammation and Mood Disorders

  • Chronic mood disorders, often seen as purely psychiatric, are frequently linked to brain inflammation.
  • Addressing brain inflammation can lead to significant improvements in seemingly incurable conditions.
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