My quest to cure prion disease — before it's too late | Sonia Vallabh
Jul 16, 2024
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Biomedical researcher Sonia Vallabh shares her quest to cure prion disease after discovering her genetic mutation. The podcast delves into her journey, from genetic prion disease discovery to research pursuits for therapy. It explores using CRISPR for prevention, challenges of testing new medicines, and reflections on family, genetics, and scientific breakthroughs.
Sonia Vallabh's journey emphasizes the significance of proactive measures against prion disease.
Research focusing on deactivating disease-causing proteins before brain damage holds promise for prevention strategies.
Deep dives
Sonia Bolev's Life-Changing Diagnosis
Sonia Bolev's journey into science and medicine was kick-started by a personal diagnosis that revealed her genetic risk for a fatal prion disease. After discovering her high-risk mutation, Sonia and her husband, Eric, embarked on a transformative path of education and career change to confront the disease head-on. Their commitment led them to lead a lab at the Broad Institute dedicated to developing therapies for prion disease.
Understanding Prion Disease and Treatment Approach
Prion disease, caused by abnormal proteins corrupting brain cells, presents a unique challenge in medicine. Instead of directly targeting the problematic proteins, Sonia and Eric's approach emphasizes preventing the disease before it manifests. By seeking to deactivate the disease-causing protein before it harms neurons, they aim to develop a therapy that could potentially prevent the onset of prion disease.
The Quest for Disease Prevention and Humility in Science
Sonia's mission highlights the importance of prevention in tackling diseases like prion disease. Despite the complexities and uncertainties involved, she underscores the need to aim higher and prioritize preventive measures over reactive treatments. By combining audacity and humility in their scientific pursuit, Sonia and Eric strive to push boundaries and respect the vast unknowns of the brain to protect irreplaceable human lives.
Biomedical researcher Sonia Vallabh's life was turned upside down when she learned she had the genetic mutation for a rare and fatal illness, prion disease, that could strike at any time. Thirteen years later, her search for a cure has led to new insights about how to catch and prevent disease — and how to honor our grandest, most mysterious inheritance: our brains.