Up First from NPR Can Psychedelic Therapy Go Mainstream?
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Aug 3, 2025 
Rachel Carlson, a producer for NPR's science podcast Shortwave, delves into the fascinating world of psychedelic therapy. She shares insights on the promising potential of psychedelics for treating PTSD and depression, while navigating the complex legal landscape that hinders their prescription. The discussion highlights ketamine's unique role and the growing trend of at-home therapies, emphasizing the fine balance between hope and caution in this evolving field. Listeners will find the blend of science and personal experience truly eye-opening.
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Psychedelics Boost Brain Plasticity
- Psychedelics may work by increasing neuroplasticity, helping neurons regrow connections quickly.
- This could lead to fast, lasting therapeutic effects compared to traditional antidepressants.
Legal Status Limits Psychedelic Use
- Psychedelics are Schedule I substances and illegal federally, blocking widespread medical use.
- None have FDA approval for medical treatment yet, despite ongoing clinical trials.
The Challenge of Psychedelic Trips
- The psychedelic 'trip' presents risks and logistical issues for mainstream medical use.
- Scientists question if therapeutic benefits can be achieved without the hallucinogenic experience.