The Metabolic Link Ketosis in Models of Muscle Atrophy | Journal Club | The Metabolic Link Ep.10
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Mar 28, 2023 Co-hosts delve into intriguing studies about ketosis and muscle atrophy, tackling how ketone bodies influence muscle health. They discuss conflicting results on ketogenic diets in atrophied models, emphasizing the role of calorie and protein restriction. The hosts explore how ketone supplementation can aid recovery without dietary changes and highlight its potential in cancer cachexia. They also examine evolutionary mechanisms behind ketones' protective effects on muscle during nutrient deprivation, questioning the nuances in implementing these findings clinically.
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Ketogenic Diet May Mask Calorie Restriction Effects
- The Shanghai hindlimb ischemia study likely reflected calorie and protein restriction rather than a well-implemented ketogenic diet.
- Calorie restriction in rodents commonly impairs wound healing and confounds ketogenic diet interpretation.
Control Calories And Protein In Diet Studies
- Verify animals maintain calories and protein when testing ketogenic diets to avoid confounding by starvation.
- Measure and report food intake, body weight, glucose, and ketones across the study to clarify metabolic state.
High Rodent Ketones Often Signal Starvation
- Very high rodent ketone levels (2–2.7 mM) usually indicate severe calorie restriction, not just diet composition.
- Such metabolic extremes drive weight loss and large glucose drops that alter healing biology.