1) Sydenham chorea and 2) Topic of the month: Historical interviews. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Jeff Waugh interviews Dr. Fabienne Brilot-Turville about her paper on antibody binding to neuronal surface in Sydenham chorea. In the next segment, Dr. Stacey Clardy is reading our e-Pearl of the week about fragile X-associated tremor ataxia syndrome. In the next part of the podcast Dr. Farrah Mateen completes our historical interviews for the month by interviewing Dr. Jerome Posner. In concluding, there is a brief statement where to find other up-to date patient information and current Patient Page. The participants had nothing to disclose except Drs. Brilot-Turville, Clardy and Mateen.Dr. Brilot-Turville has received research support from the Tourette Syndrome Association, USA, the Brain Foundation Australia, and the Trish Multiple Sclerosis Foundation Australia. Dr. Clardy serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Mateen served on the editorial team for the Neurology® Resident and Fellow Section and is supported by the 2010 Practice Research Grant from the American Academy of Neurology.