JAMA Editors' Summary JAMA at CCR Down Under, Hot Topics in Neonatology, Risk-Based Breast Cancer Screening, and more
9 snips
Dec 12, 2025 Discover the latest breakthroughs in precision medicine with trials showing promising results for organ dysfunction and sepsis therapy. Dive into the challenges of cryopreserved platelets and learn about innovative approaches to pediatric care in managing PDA. Explore an update on febrile infants' prediction rules and the impacts of risk-based breast cancer screening. Uncover trends in vitamin K refusals and the ongoing debate in obesity management and CAR T-cell therapy advancements.
AI Snips
Chapters
Transcript
Episode notes
Precision Immunotherapy Shows Promise
- Precision immunotherapy tailored to sepsis endotypes improved organ dysfunction by day nine in the ImmunoCEP trial.
- Anakinra increased anemia and interferon gamma increased hemorrhage, highlighting therapy-specific harms.
Cryopreserved Platelets Not Equivalent
- Cryopreserved platelets failed to meet non-inferiority for reducing chest drain bleeding after cardiac surgery in CLIP2.
- They were linked to greater blood loss and more transfusions, raising concerns for routine substitution.
Automation Didn’t Shorten Ventilation Time
- Early automated closed-loop ventilation did not increase ventilator-free days at 28 days in the ACTIVE trial.
- Large randomized evidence suggests automation alone may not shorten ventilation time versus conventional care.