Oncotarget

New Insights into HER2-Mutated Non-Small Cell Lung Cancer in Brazil

Oct 8, 2025
Lung cancer's genetic complexities take center stage, particularly with the HER2 mutation that presents unique treatment challenges. Researchers from Northeastern Brazil unveil crucial insights into this rare mutation in non-small cell lung cancer. They highlight significant diversity in mutation types and the frequent co-occurrence with aggressive mutations like TP53. The discussion emphasizes the gap in access to targeted therapies and the urgent need for genomic equity in underserved regions. Their findings advocate for comprehensive genomic testing to improve diagnostics and treatment outcomes.
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INSIGHT

HER2 Mutations Are A Distinct NSCLC Subgroup

  • HER2 mutations occur in about 2–4% of NSCLC and pose unique diagnostic and treatment challenges.
  • Research from high-income countries may not reflect genetic diversity in other regions, limiting care equity.
ANECDOTE

Brazilian Study Of 13 HER2 Cases

  • Researchers in northeastern Brazil analyzed 13 HER2-mutated NSCLC cases using clinical, pathological, and genomic data.
  • They found common exon 20 insertions and rarer mutations like V842I and Q709L, showing high genetic diversity.
INSIGHT

Co-Mutations And Low TMB Affect Treatment

  • More than half the patients had co-mutations, especially TP53, linked to aggressive behavior and resistance.
  • Most tumors showed low tumor mutation burden, indicating likely limited benefit from immunotherapy.
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