Don't Worry About the Vase Podcast Monthly Roundup #37: December 2026
Dec 12, 2025
The discussion kicks off with a compelling case against gain-of-function research, warning of its inherent risks. Insights into the dynamics of pricing reveal how they signal incentives in our economy. There's a critical look at the culture of condemnation and job risks tied to compensation. The debate extends to gaming innovations and whether unbeatable decks enhance or hinder player experience. Finally, attention turns to robust child safety measures on platforms like Roblox and the complexities of immigration policy for skilled workers.
AI Snips
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Transcript
Episode notes
Ban Reckless Gain-Of-Function Work
- Gain-of-function research has an abysmal risk-reward profile even when handled properly.
- Zvi argues the practice is insane and can produce pathogens that could cause catastrophic pandemics.
Chimeric Coronavirus Done In Low-Security Lab
- A China study made chimeric coronaviruses that infect human cells and kill mice, done in a BSL-2 lab.
- Zvi highlights the authors thanked Zhengli Shi and others and notes no arrests followed this risky work.
Loosen Home-Business Zoning Rules
- Relax zoning restrictions on home-based businesses to unlock economic activity and creativity.
- Zvi suggests being dramatically more chill while maintaining sensible limits and enforcement.
