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The Addicted Mind Podcast

251: The Neuroscience of Addiction: A Game-Changing Approach with Dr. Paul Kenny

Sep 18, 2023
Dr. Paul Kenny, a distinguished figure in neuroscience and addiction research, discusses groundbreaking research on addiction treatment, the relationship between drugs, addiction, and satiety, and the potential use of GLP1 modulators in treating alcohol and substance use disorders. They also delve into the complexities of addiction and the struggle individuals face to ignore addiction urges.
45:59

Episode guests

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Quick takeaways

  • GLP-1 modulators have shown promising effects in reducing cravings and consumption in individuals with substance use disorders, offering a new perspective on addiction therapeutics.
  • The effects of GLP-1 modulators on addiction may involve peripheral sensory neurons, opening up new possibilities for addiction treatment.

Deep dives

GLP-1 modulators and their effects on addiction

GLP-1 modulators, such as semaglutides, have shown promising effects in reducing cravings and consumption in individuals with alcohol use disorder and tobacco smoking. These drugs mimic the actions of GLP-1, a hormone that regulates appetite and blood glucose levels. By stimulating GLP-1 receptors in the brain and potentially in peripheral sensory neurons, the drugs can activate satiety circuits, decreasing the desire for drugs. Clinical trials are being conducted to assess the effectiveness of GLP-1 modulators in treating opioid use disorder. The goal is to enhance the therapeutic response of first-line treatments and possibly provide standalone benefits. The Cure Addiction Now foundation supports innovative research projects like this that may not receive traditional funding yet have the potential to make significant breakthroughs in addiction treatment. It is important to overcome the stigma associated with addiction and seek help from professionals and support networks for a successful recovery.

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