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Oncotarget

Why Some Breast Cancer Treatments Stop Working

Mar 24, 2025
Discover why some breast cancer treatments stop working and the critical role of signaling pathways. Researchers reveal how mutations and altered cell communication support tumor survival and resistance. Key pathways like PI3K/Akt/mTOR and HER2 are discussed, shedding light on their impact on treatment response. The insights aim to enhance understanding and pave the way for novel therapeutic strategies. Tune in for an eye-opening exploration of the challenges in treating this prevalent cancer!
04:11

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Quick takeaways

  • Disruptions in key signaling pathways like PI3K/Akt/mTOR are pivotal in breast cancer treatment resistance and tumor progression.
  • Emerging therapeutic strategies that target specific genetic characteristics of tumors may significantly improve outcomes for aggressive breast cancer cases.

Deep dives

Significance of Signaling Pathways in Breast Cancer Treatment Resistance

The review emphasizes how disruptions in signaling pathways within breast cancer cells can lead to treatment resistance and tumor progression. Various pathways, such as PI3K-AKT and RAS-RAF, play critical roles in regulating cell growth and division, and their alteration can significantly impact therapy response. Specifically, the overactivation of the PI3K pathway, linked to mutations or the loss of tumor suppressing proteins like P10, is observed in a substantial proportion of breast cancer cases, indicating its pivotal role in oncogenesis. This understanding sheds light on the mechanisms behind therapy failures, highlighting the necessity for targeted approaches in treatment.

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