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Annals On Call Podcast

Low-Dose Aspirin and Iron Deficiency Anemia

Sep 18, 2023
Dr. Centor and Dr. Zoe McQuilten discuss the risk of anemia in older patients taking aspirin. They explore a study revealing that low-dose aspirin did not prolong disability-free survival and increased the risk of major bleeding. The podcast examines iron deficiency in older individuals, the impact of aspirin on anemia and iron levels, and the difference between aspirin dosages. A study highlights the increased risk of major bleeding, iron deficiency, and significant anemia with low-dose aspirin. Caution is advised in using aspirin in cardiovascular disease patients and monitoring for iron deficiency is emphasized.
17:28

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Quick takeaways

  • Aspirin use for primary prevention in older patients increases the risk of developing anemia over five years and leads to a steeper decline in hemoglobin levels compared to placebo.
  • Lodos Aspirin is associated with a higher proportion of iron deficiency in elderly individuals, as indicated by lower ferritin levels, highlighting the potential impact on iron levels.

Deep dives

Impact of Lodos Aspirin on Iron Deficiency and Anemia in Elderly: Study Analysis

A study analyzed the impact of Lodos Aspirin on iron deficiency and anemia in elderly individuals. The study was part of the Aspirin in Reducing Events in the Elderly trial, which evaluated the effects of aspirin in healthy older individuals for primary prevention. The trial showed that while aspirin did not prolong disability-free survival, it increased the risk of major bleeding. As part of the trial, participants had regular hemoglobin measurements, allowing researchers to assess the development of anemia. The study found that the risk of developing anemia over five years was higher in the aspirin group compared to the placebo group. Additionally, participants receiving aspirin had a steeper decline in hemoglobin levels compared to those on placebo.

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