Bloody Minded Episode 74 - Christmas Disease | A Bonus Beginners Bonanza on Haemophilia B
Dec 23, 2025
Delve into the festive unraveling of Christmas Disease, also known as haemophilia B. Discover the fascinating history behind its name, tied to patient Stephen Christmas. Learn about the evolution of coagulation studies and the unique role of the Christmas factor. The hosts also tackle modern treatments, including groundbreaking gene therapy advancements. Plus, enjoy a dose of humor with Christmas-themed songs, making complex medical topics both engaging and entertaining!
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Haemophilia B Is Factor IX Deficiency
- Haemophilia B is a deficiency of coagulation factor IX distinct from haemophilia A which involves factor VIII.
- Use the specific name 'haemophilia B' rather than the eponym 'Christmas disease' for clarity.
Discovery Named After Stephen Christmas
- The first identified haemophilia B patient was Stephen Christmas and the discovery was reported on December 27, 1952.
- That origin gave rise to the eponym 'Christmas disease' still used colloquially.
Mixing Tests Originated In The 1950s
- Early investigators used mixing tests to differentiate factor deficiencies from inhibitors by observing correction with normal plasma.
- This historical work laid the foundation for modern mixing studies and factor assays.