
Reality Life with Kate Casey Ep. - 1445 - SATURDAY SERIES: KAREN “DUFF” DUFFY
Nov 1, 2025
Karen “Duff” Duffy, a former MTV VJ, actress, and bestselling author, shares her vivid memories from MTV, including wild encounters with celebrities like Bill Murray and George Clooney. She reflects on her transition from the spotlight to navigating life with chronic pain after her diagnosis of CNS sarcoidosis. Duffy discusses her daily gratitude practice, her journey into chaplaincy, and how writing became a healing outlet. Her stories blend humor and resilience, revealing that life's challenges can be faced with wit and grace.
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How She Landed MTV
- Karen Duffy describes breaking into MTV by making an unsolicited videotape and hustling her way into the job.
- She emphasizes transferable skills from gerontology and volunteering that helped her connect on camera.
Friendships From The MTV Era
- Duffy recounts close friendships formed at MTV that lasted, including Bill Murray and Bono.
- She shares playful memories showing how those relationships endured beyond fame.
Embrace Cultural Impermanence
- Duffy reflects on MTV's impermanence and how cultural institutions evolve into new formats.
- She accepts career cycles and values the lessons and relationships from that era.







