The Carlat Psychiatry Podcast A More Powerful Antidepressant
Nov 24, 2025
Discover the groundbreaking effects of SNT TMS on treatment-resistant depression, boasting a staggering 79% remission rate. Dive into the origins of this innovative therapy with insights from the 2017 Stanford trial that altered its protocol mid-study. Learn how SNT enhances brain targeting through fMRI while differentiating itself from traditional TMS and psychedelics. The compressed five-day schedule allows for practical, rapid responses, stacking treatments for maximum impact. Get ready for a deep dive into the future of antidepressant therapies!
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Record-Breaking Remission Rates
- The SNT protocol produced an unprecedented effect size and rapid remission in highly treatment-resistant patients.
- Chris Aiken reports 79% remission vs 7% with sham after an average of five failed antidepressants.
Power Without Breaking The Blind
- SNT achieved rapid, large effects while preserving blinding in the trial.
- Participants could not tell active from sham despite dramatic improvement over five days.
Offer The Five-Day Intensive Option
- Offer SNT as an intensive five-day option for patients who need rapid improvement.
- Expect 10-minute ITBS sessions repeated hourly across 10-hour treatment days.
