Frontotemporal dementia (FTD) is the most common form of dementia for people under the age of 65. As its name implies FTD involves degeneration of neurons in the frontal and parietal lobes and depending upon which neurons degenerate symptoms may mainly involve changes in personality and social behavior, speech and language (aphasia), or difficulty with body movements. UCSF neurologist Bill Seeley has devoted his career to understanding what goes wrong in FTD and using this information to develop ways of early diagnosis and treatments that slow or halt the progression of the disease. Here he talks about the genetics, and cellular and molecular mechanisms responsible for FTD and emerging treatments.
LINKS
file:///Users/markmattson/Downloads/s41572-023-00447-0%20(2).pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909835/pdf/nihms204382.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647117/pdf/415_2019_Article_9363.pdf
Brain Ponderings podcast with Mark Mattson