

REPLAY: How Not To Die with David Sinclair and David Walliams (Brave New World preview)
Feb 12, 2025
David Sinclair, a pioneering Harvard genetics professor specializing in aging, teams up with humorous writer and comedian David Walliams to tackle the intriguing question of eternal life. They explore groundbreaking research on age as a malleable state and share practical tips for reversing biological clocks. The conversation touches on the balance between indulgence and a healthy lifestyle, the impact of diet on longevity, and innovative health tracking techniques that estimate one's biological age. Expect laughter and enlightenment on living well!
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Walliams' Motivation
- David Walliams' father died at 71 from hemochromatosis, a genetic condition.
- This experience made him contemplate aging and his own mortality, motivating him to explore longevity.
Mapping Biological Age
- Biological age can be mapped by measuring blood parameters like iron, hormones, blood sugar, and inflammation.
- These parameters are compared to age-related changes to determine an "inner age."
Dietary Recommendations
- Reduce sugar intake and eat less often to maintain steady glucose levels.
- This prevents blood sugar spikes and dips, reducing hunger and improving concentration.