This Podcast for the Neurology Journal begins and closes with Dr. John H. Noseworthy, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Jeff Burns interview Dr. Rachelle Smith Doody about her paper on donepezil treatment of patients with MCI. In the next segment, Dr. Ted Burns is reading our e-Pearl of the week about demyelinating polyneuropathy. The podcast concludes where Dr. Alberto Espay interviews Dr. Russell Swerdlow for the Lesson of the Week segment. The participants had nothing to disclose except for Dr. Espay who has received personal compensation as consultant for Boehringer-Ingelheim, grant support from Codman, Allergan, Medtronic, and CleveMed and honoraria from UCB-Schwarz Pharma, Medtronic and Novartis.