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High carbohydrate diets, particularly those rich in refined sugars and starches, have a detrimental impact on vitamin B1 levels in the body. These sugars deplete B1, leading to various symptoms that many may mistakenly attribute to other health issues. An individual's experience with excessive sugar consumption, including refined carbohydrates like pasta and desserts, illustrates this relationship and highlights the resulting health complications such as restless leg syndrome and prediabetes. Ultimately, a significant portion of the U.S. population unknowingly participates in this 'experiment' through their dietary choices, consuming a diet that excessively relies on refined carbohydrates, leading to vitamin B1 deficiency.