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Mastering Nutrition

How to slow or reverse graying of hair? | Masterjohn Q&A Files #321

Aug 14, 2023
Exploring ways to slow or reverse graying of hair by addressing weak links in energy signaling, infrastructure of energy production, and antioxidant protection. Topics include the relationship between carbohydrate intake and thyroid hormone production, biology and factors contributing to hair graying, the effects of calcium pentathenate, and inborn errors of metabolism's influence on graying hair.
22:17

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Quick takeaways

  • Finding and fixing the weakest link is key to slowing or reversing graying of hair, by addressing factors like energy abundance signaling, biochemical infrastructure of energy production, and antioxidant protection.
  • Exploring and understanding the diverse factors that influence hair pigmentation, such as neuroendocrine signaling, oxidative damage, and risk factors like obesity and high blood pressure, can help identify personalized solutions.

Deep dives

Understanding the Biology of Hair Graying

Hair pigmentation is regulated by neuropeptides in the brain and the hypothalamic-pituitary-thyroidal axis. Factors like growth factors, inflammatory mediators, and circadian rhythm play a role. The production of neuropeptides depends on nutrients like vitamin C, copper, zinc, and glycine. Additionally, thyroid hormone production requires iodine, sufficient calories, body fat, and an appropriate macronutrient balance. Energy metabolism and antioxidant protection are vital due to the oxidative nature of producing thyroid hormone and melanin pigment. Gray hair is associated with reduced neuroendocrine signaling, oxidative damage, and risk factors like obesity and high blood pressure.

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