Tirzepatide to Retatrutide: The Ultimate Transition Guide (Dosing & Protocols)
Jul 11, 2025
Learn about the transition from tirzepatide to retatrutide, focusing on their distinct mechanisms and how to optimize weight loss. Discover practical dosing strategies and tips for managing side effects. This insightful discussion highlights the benefits of retatrutide for metabolic health and offers a comprehensive guide for those considering the switch. Whether you're looking to enhance fat loss or stay updated on the latest peptide protocols, this conversation provides valuable insights.
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insights INSIGHT
Dual vs Triple Receptor Agonism
Tirzepatide targets two receptors: GLP-1 and GIP, while Retatrutide targets three including glucagon.\n- The addition of glucagon receptor agonism in Retatrutide provides enhanced metabolic benefits and fat loss.
insights INSIGHT
Tirzepatide's Imbalanced Coagonism
Tirzepatide has stronger GIP receptor activation than GLP-1, reducing side effects.\n- This design leads to better metabolic benefits with fewer gastrointestinal issues compared to semaglutide.
insights INSIGHT
Glucagon's Role in Retatrutide
Retatrutide's glucagon receptor activation boosts energy expenditure and liver fat reduction.\n- GLP-1 and GIP effects counterbalance glucose increases from glucagon, improving glycemia.
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Are you thinking about switching from tirzepatide to retatrutide? In this video, I’ll walk you through everything you need to know about making the transition—from the science and mechanisms, to real-world dosing strategies and the side effect differences I see in my community. If you’re looking for maximum fat loss and the most up-to-date peptide protocols, this video is for you.
Timestamps
0:00 – Introduction: Why the switch from tirzepatide to retatrutide is happening 0:45 – Clinical background: Compounding issues and the rising popularity of retatrutide 1:30 – My transition philosophy: Gradual tapering and best practices 2:04 – Mechanisms: How tirzepatide and retatrutide work in the body 3:10 – Tirzepatide: GIP and GLP-1 agonism explained 3:54 – Why tirzepatide has fewer side effects vs semaglutide 4:01 – Retatrutide: What does triple agonism mean? 4:42 – Metabolic advantages: Glucagon receptor activation, liver fat reduction, energy expenditure 5:45 – Head-to-head comparison: Why retatrutide is stronger for fat loss 6:51 – Dose escalation: How to titrate both drugs (side effects & protocol) 7:56 – Study outcomes: Average weight loss on both drugs 9:10 – A1C improvements: Comparing metabolic health markers 10:00 – Retatrutide’s liver benefits and impact on longevity 11:02 – What to expect when you switch: Side effects, hunger, and adaptation 12:02 – Appetite differences: Why tirzepatide suppresses appetite more at equal doses 13:30 – Side effect management: GI symptoms, heart rate, and tips 14:02 – My detailed titration schedule for switching safely 16:50 – Can you mix tirzepatide and retatrutide? 17:39 – Why minimum effective dosing matters and other fat loss pathways 18:01 – Final thoughts: Community support, feedback, and closing
In this video you’ll learn: • The step-by-step protocol to taper down tirzepatide and introduce retatrutide safely • Key differences in mechanisms (GIP/GLP-1 vs GIP/GLP-1/Glucagon) • Real world data on weight loss, A1C, and fatty liver reduction • My honest recommendations for side effect management • How to listen to your body and titrate up for maximum effect • Answers to common questions: can you combine both, and is the switch right for you?
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