78. Therapeutic Plasma Exchange for Longevity with Dr. Layke: Real Anti-Aging Results

Therapeutic Plasma Exchange (TPE) has quickly become one of the most discussed longevity tools, bridging traditional medicine with cutting-edge regenerative therapies. In this episode, Dr. Greg Jones sits down with Dr. John Layke—Beverly Hills plastic surgeon and leading longevity physician—to unpack the science, clinical applications, and real-world results behind TPE. 

Dr. Layke explains how TPE works, why it has been used for decades in conventional medicine, and how modern research now points to its role in reducing inflammation, clearing immune complexes, and supporting metabolic health. You’ll learn what is removed during plasma filtration, what patients commonly feel after a session, and how TPE interacts with other regenerative tools.

The episode also explores how senescent cells, chronic inflammation, lifestyle choices, and hormone balance shape health span. 

Whether you’re curious about emerging anti-aging therapies or evaluating whether TPE fits into your own health optimization plan, this discussion delivers a practical, science-driven guide to what’s available now—and what the future of regenerative medicine may look like.

📌 Dr. John Layke

Dr. John Layke is a leading board-certified plastic and reconstructive surgeon based in Beverly Hills.  As the co-founder of Proactive Longevity, Dr. Layke also plays a key role in the fields of anti-aging and regenerative medicine. He has been an early adopter of stem cell therapy and exosome treatments, using these tools to support both aesthetic goals and overall wellness. Known for his balance of artistry and science, Dr. Layke is committed to helping people look and feel their best, and often shares forward-thinking insights on longevity and the future of regenerative care.

🔗 Learn more about Dr. John Layke

Website: www.johnlayke.com | https://theproactivelongevity.com

Instagram: www.instagram.com/drjlayke

🔗Connect with Dr. Greg Jones

Instagram: @doctorjones_doctorjones 

Enovative Wellness Center: https://enovativewellness.com/ 

Learn more about Dr. Jones: https://www.drjonesnmd.com/

• Welcome & episode introduction (00:00 - 01:31)
• Dr. Layke’s transition from plastic surgery to longevity (02:02 - 02:45)
• Discovering regenerative therapies worldwide (02:45 - 03:15)
• Launching a longevity clinic in Cabo (03:15 - 03:52)
• What TPE is (04:57 - 05:22)
• How plasma accumulates inflammatory and immune waste (05:22 - 06:24)
• Do platelets or clotting factors drop post-TPE? (06:29 - 07:43)
• TPE’s influence on chronic inflammation & disease pathways (07:38 - 08:04)
• What TPE removes (08:21 - 08:56)
• The “blood oil change” analogy (08:56 - 09:50)
• TPE’s original medical purpose (09:51 - 10:24)
• The value of plasma dilution (10:24 - 11:52)
• Autoimmune conditions with promising TPE outcomes (11:53 - 13:04)
• Common post-session benefits (13:26 - 14:36)
• Mario Lopez’s TPE experience & rising public curiosity (14:41 - 16:16)
• Biological age improvements (16:20 - 18:43)
• Ideal TPE candidates (18:47 - 20:42)
• Who may not qualify for TPE (22:16 - 23:44)
• How TPE pairs with NK cells, stem cells & exosomes (23:45 - 26:50)
• Safety protocols (27:05 - 30:49)
• Preparing for TPE (30:54 - 33:16)
• TPE vs. eBOO: separating evidence from hype (33:16 - 35:45)
• The growing accessibility of longevity medicine (35:45 - 37:37)
• The peptide segment (37:37 - 38:52)
• Growth hormone peptides (41:22 - 42:34)
• Peptide blends (42:35 - 44:10)
• Senolytics: FOXO4-DRI & clearing senescent cells (44:16 - 45:20)
• Peptide injection lessons learned (45:21 - 48:00)
• C-Max vs. C-Link for cognitive enhancement (48:01 - 49:50)
• Where TPE fits into the future of anti-aging medicine (50:02 - 51:25)
• Predictive models: could humans live to 150? (51:26 - 52:46)
• Lifestyle, hormones & inflammation in aging (52:47 - 53:50)
• Final actionable longevity guidance (53:51 - 56:27)
• How to follow Dr. Layke’s work (56:27 - 57:30)
• Closing thoughts (57:30 - 58:26)