Blood Podcast Prolonged response after stopping TPO-RA in ITP, TP53 mutations and myelofibrosis outcomes, clinical picture of ERCC6L2 disease, where variants predispose to marrow failure and malignancy
24 snips
Jun 8, 2023 AI Snips
Chapters
Transcript
Durable Responses After TPO-RA Discontinuation
- A prospective trial found 56.2% of ITP patients sustained response 24 weeks after tapering T-PoRAs.
- About one-third maintained complete response at both 24 and 52 weeks.
Taper And Trial Off TPO‑RAs
- The authors support progressive tapering and discontinuation of T-PoRAs for chronic ITP responders.
- Retreatment was effective: 11 of 12 relapsed patients regained complete responses.
CD69 On CD8 T Cells Predicts Relapse
- Single-cell RNAseq and flow cytometry showed higher CD69 expression on CD8+ T cells in relapsing patients.
- CD69 could serve as a predictive biomarker for post-taper relapse.