Neurology Exam Prep Podcast
Episode 74 - Neurosyphilis
Dec 31, 2024
In this engaging discussion, Dr. Aaron Bower, an attending physician at Yale specializing in neuroimmunology, delves into the complexities of neurosyphilis. He describes the distinct stages of syphilis and its alarming rise in incidence, especially in the context of HIV co-infection. Dr. Bower highlights both early and late neurological manifestations, including syphilitic meningitis and complications like tabes dorsalis. The conversation also covers diagnostic approaches and CDC-recommended treatment protocols, emphasizing the critical need for effective monitoring.
28:45
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Quick takeaways
- The rising incidence of syphilis cases in the U.S. demands attention, especially considering that about 3.5% develop into neurosyphilis.
- Understanding the phases of syphilis and the importance of timely diagnostic testing are crucial for effective treatment and prevention of complications.
Deep dives
Epidemiology and Demographics of Syphilis
Recent trends indicate a concerning rise in the rates of primary and secondary syphilis cases in the United States, with an estimated 9.5 cases per 100,000 population reported in 2017. A significant portion, about 3.5%, of these cases develops into neurosyphilis. Demographically, males account for a large majority of cases, constituting around 86% in 2018, while the rates for females have doubled from 2014 to 2018. Moreover, a notable co-infection with HIV occurs in approximately 42% of syphilis cases, highlighting the need for comprehensive evaluations for both infections in the clinical setting.
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