The Optispan Podcast with Matt Kaeberlein

Blood Cleaning: Cuts Age Biomarkers 2.6 Years in 90 Days!

7 snips
Oct 21, 2025
Dr. Brad Younggren, an emergency physician and CEO at Circulate, shares his journey from combat to longevity science. They dive into the innovative Therapeutic Plasma Exchange (TPE), likening it to an 'oil change for your blood.' Discover how TPE may reduce biological age by 2.6 years, tackling toxins like microplastics and chronic diseases. Dr. Younggren discusses clinical trial insights, the science of parabiosis, and the impressive results observed, while sharing patient stories, including improvements in long COVID symptoms.
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INSIGHT

How TPE Works

  • Therapeutic plasma exchange (TPE) removes plasma and replaces it with albumin and supportive electrolytes using a centrifuge.
  • The procedure targets circulating proteins, cytokines, and immunomodulatory molecules linked to aging and inflammation.
INSIGHT

Parabiosis Informs Human Trials

  • Parabiosis experiments show young blood ages old animals and old blood ages young animals.
  • These findings motivated human TPE trials to test whether circulating factors drive age-related decline.
INSIGHT

Rigorous Sham Control Design

  • The Circulate trial used a realistic sham control with machines draped and IV lines masked to blind participants.
  • This design controlled strong placebo effects common in procedural interventions.
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