The Fellow on Call: The Heme/Onc Podcast Episode 054: Breast Cancer Series, Pt. 3-Breast Cancer Vocabulary
Apr 26, 2023
Dive into the complex vocabulary surrounding breast cancer. Unravel important terms like ER/PR and HER2 that shape diagnosis and treatment. Learn about the significance of different tumor types and grading systems. Explore molecular subtypes and genomic assays that guide personalized care. Get the lowdown on surgical terminology and TNM staging mnemonics. Plus, discover essential endpoints in clinical trials. This insightful journey will empower you to better understand and communicate the nuances of breast cancer.
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Determine Hormone Receptor Status With IHC
- Use immunohistochemistry (IHC) to determine ER and PR status for treatment planning.
- Consider a tumor ER positive if ≥1% of cells stain for estrogen receptor.
Follow IHC With FISH For Equivocal HER2
- Use IHC to screen HER2 and reflex to FISH when IHC is 2+.
- Call HER2 positive if FISH shows HER2 signal >6 or HER2/CEP17 ratio >2.
Morphology Explains Tumor Origin
- Classify breast tumors by morphology as lobular or ductal to understand origin.
- 'No special type' usually means common invasive ductal carcinoma without unusual histology.