Your bloodwork looks normal. Your doctor says you’re fine. But you still feel exhausted, inflamed, anxious—or worse.

In this episode, Dave Asprey talks with Dr. Daniel Pompa, a leading voice in cellular detox and root-cause healing, to expose the hidden stressors hijacking your energy, hormones, and metabolism—even when your labs say you’re healthy.

Dr. Pompa shares his personal health collapse and reveals how cellular dysfunction, neurotoxicity, and hormone resistance drive the chronic fatigue epidemic. If you’ve ever felt dismissed by “perfect” bloodwork, this conversation will rewire how you think about sickness—and show you how to reclaim real, lasting wellness.

What You’ll Learn in This Episode:

• Why your bloodwork can be “perfect” while your cells are on fire

• The overlooked hormone resistances sabotaging your energy and metabolism

• The 3-legged stool of chronic illness—and what actually drives disease

• What “upstream detox” really means, and why most cleanses make you worse

• Why toxins trigger genetic expression (and how to shut that down)

• How to fix unexplainable fatigue, anxiety, and weight gain from the inside out

• Why true healing starts with fixing the cell, not the symptom

It’s time to stop chasing symptoms—and start upgrading from the root.

**Check out Dr. Pompas EXCLUSIVE protocol built for The Human Upgrade listeners at davetestkit.com and use code ‘10OFF’ for a discount!**

SPONSORS

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.

-Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Dr. Pompa’s Website – https://drpompa.com/

• Dr. Pompa’s Instagram - https://www.instagram.com/drpompa/?hl=en

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 Trailer

• 00:55 Intro

• 01:10 Healthy Is the New Sick

• 02:27 Bloodwork & Hormone Resistance

• 04:32 Dr. Pompa’s Health Collapse

• 08:38 Toxins & Environmental Triggers

• 15:01 Why Most Detox Fails

• 29:16 The 5 Rs of Cellular Healing

• 37:06 Olive Oil: Cure or Concern?

• 38:11 Fat Balance for Energy

• 42:13 Cholesterol & Saturated Fat

• 46:26 Restoring Cellular Energy

• 51:08 The Power of Diet Variation

• 56:57 Plant Toxins Explained

• 01:03:28 Emotional & Spiritual Detox

• 01:13:55 Final Thoughts

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How to Talk to Girls about Anxiety, Depression, and Social Media with Donna Nakazawa