The Clinical Problem Solvers Episode 300: Schema Episode – Cytopenias
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Aug 23, 2023 Jack, AMK, Maddy, and Sharmin discuss approaching cytopenias and DVTs, highlighting evaluation methods, treatment options, and differential diagnoses.
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Thrombocytopenia Evaluation
- When evaluating thrombocytopenia, first confirm it's real, not pseudothrombocytopenia.
- Consider emergent causes like DIC, TTP, and HIT, especially with schistocytes or recent heparin use.
Thrombocytopenia Framework
- Thrombocytopenia causes can be categorized by platelet lifecycle stages: reduced production, peripheral destruction, and sequestration.
- Reduced production often involves bone marrow issues; peripheral destruction can be immune-mediated or consumptive; sequestration occurs with splenomegaly.
DVT Management
- DVT management involves determining initial and long-term treatment and duration.
- Consider IVC filters if absolute contraindications to anticoagulation exist (e.g., active bleeding, intracranial hemorrhage).
