Two Onc Docs
Multiple Myeloma 2025 x Dr. Vincent Rajkumar Part 1
Feb 3, 2025
This week, Dr. Vincent Rajkumar, a leading expert in multiple myeloma from the Mayo Clinic, shares his insights into this complex condition. He covers vital topics like the common symptoms, including bone lesions and anemia, and explains the SLIM-CRAB diagnostic criteria. Dr. Rajkumar discusses the prevalence of M proteins, risk factors, and the disparities in diagnosis related to race. He also unpacks treatment strategies, emphasizing the significance of minimal residual disease (MRD) and personalized approaches to maintenance therapy.
17:34
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Quick takeaways
- Multiple myeloma symptoms encompass lytic bone lesions, renal failure, anemia, and infections which require effective diagnosis and treatment.
- The diagnostic process has advanced to utilize the SLIM-CRAB criteria, integrating new biomarkers for better identification of multiple myeloma.
Deep dives
Clinical Presentation and Diagnostic Criteria of Multiple Myeloma
Multiple myeloma typically presents with symptoms such as lytic bone lesions, which can lead to pain and fractures, as well as renal failure and anemia. Patients may also experience infections as part of their clinical presentation. The diagnostic criteria require evidence of a clonal plasma cell disorder, commonly represented by the acronym CRAB, which stands for hypercalcemia, renal failure, anemia, and bone lesions. Recent updates have introduced the SLIM-CRAB acronym, which incorporates additional biomarkers like clonal plasma cells, serum-free light chain ratios, and MRI findings to refine the diagnostic process.
