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Histamine intolerance affects a significant portion of individuals with digestive issues, with symptoms such as reflux, bloating, diarrhea, and food reactivity. The reactivity to environmental triggers, foods, and supplements is a hallmark symptom of this condition, which can also manifest in neurological symptoms like anxiety and insomnia. Histamine is not inherently harmful; it serves essential functions in the immune system, but excessive levels lead to various unpleasant symptoms. Managing histamine levels effectively involves understanding not just the foods consumed but also factors like gut health, which plays a crucial role in histamine metabolism.