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The Joe Cohen Show
How Proline Can Make You A Hypochondriac | Supplement Deep Dive
Jun 7, 2024
Exploring the benefits of proline for collagen synthesis and recovery, the biochemical interactions with lysine and vitamin C, and severe side effects like anxiety and hypochondriac behaviors. Joe shares lessons from his experiment, emphasizing the importance of understanding genetic predispositions before supplementation.
12:08
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Quick takeaways
- High doses of proline can lead to severe anxiety and hypochondria due to increased glutamate levels.
- Supplements like NAC, P5P, and Niacin can help mitigate the impact of high glutamate levels caused by proline consumption.
Deep dives
Impact of Proline on Glutamate and Anxiety
Taking proline in high doses led to a spike in glutamate levels, causing severe anxiety and hypochondria in the podcaster, similar to the effects of AKG supplement which also increases glutamate. Due to a genetic factor slowing down glutamate breakdown, excessive proline consumption was problematic, especially when combined with AKG. This resulted in disrupted sleep patterns, anxiety, and excessive glutamate levels, leading to a recommendation against using proline.
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