Sex, Power, Suicide, and Mitochondria with Dr Natalie Yivgi-Ohana

What if the secret to treating age-related diseases and extending healthy lifespan lies within tiny cellular structures that evolved from ancient bacteria? In this mind-expanding conversation, biochemist Dr. Natalie Yivgi-Ohana reveals how mitochondria—far more than mere cellular powerhouses—control everything from hormone production to programmed cell death.

Dr. Yivgi-Ohana, founder of Minovia Therapeutics, takes us on a fascinating journey through mitochondrial science, explaining how these organelles became integrated into our cells over evolutionary history. "Mitochondria used to be bacteria that entered into the cell and formed this symbiosis," she explains, describing how this evolutionary leap enabled life to thrive in oxygen-rich environments. This bacterial heritage gives mitochondria unique properties, including their own DNA separate from our nuclear genome, which makes them both vulnerable to damage and potentially replaceable.

The revolutionary approach Minovia has pioneered involves harvesting a patient's own stem cells, enriching them with young, healthy mitochondria from donor sources like placentas, and returning these energized cells to the patient. Unlike direct mitochondrial infusions, which pose risks of immune rejection, this method has shown remarkable safety and efficacy in clinical trials for both rare pediatric diseases and age-related conditions. "Seeing a child six and a half years old in a baby stroller and then two months later he's running in a shopping mall—it's unbelievable to see the impact," Dr. Yivgi-Ohana shares.

Perhaps most surprising is the current lack of clinical testing for mitochondrial function, despite its crucial role in health. "The strongest signal for health is how well mitochondria are doing," Dr. Yivgi-Ohana emphasizes, predicting that within a decade, mitochondrial function testing will become as routine as checking hemoglobin levels. This could transform preventive medicine by identifying mitochondrial dysfunction before symptoms appear.

Explore this frontier of cellular medicine that targets both mitochondrial and immune dysfunction—two major hallmarks of aging—simultaneously. Could rejuvenating our cellular batteries be the key to extending healthy lifespan? Listen now to discover how mitochondrial science is revolutionizing our understanding of aging and disease.

https://minoviatx.com/

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