Thriving in the 21st Century: Dr. Jaffe’s Roadmap for Healing Chronic Illness

In this follow-up episode, Dr. Leland Stillman continues his conversation with Dr. Russell Jaffe—MD, PhD, clinical pathologist, immunologist, and founder of PERQUE—diving deep into the key principles behind his book Thriving in the 21st Century. This discussion unpacks Dr. Jaffe’s decades of research and clinical experience, offering a framework for preventing and reversing chronic disease through a blend of biochemical precision, lifestyle intervention, and systems-based thinking.

Dr. Jaffe outlines his “eight predictive biomarkers” model, explaining how these indicators—ranging from first morning urine pH to LRA by ELISA/ACT testing—can provide early insight into immune tolerance, metabolic resilience, and inflammatory load. The conversation touches on the pitfalls of conventional lab reference ranges, the role of high-potency, bioavailable vitamin C, and how detoxification, hydration, and alkalinity work synergistically to restore function at the cellular level. Dr. Stillman and Dr. Jaffe also discuss the root causes of oxidative stress and the clinical utility of measuring oxidized cholesterol.

This episode is ideal for clinicians, health coaches, and informed patients looking for a strategic, evidence-based approach to long-term wellness. Dr. Jaffe’s work challenges the reactive, pharmaceutical-heavy model of conventional medicine and offers a preventative roadmap rooted in physiology, nutrient synergy, and personalized care. To learn more, explore his book Thriving in the 21st Century, available now on Amazon, and visit drrusselljaffe.com for tools, resources, and practitioner education.

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