AI-powered
podcast player
Listen to all your favourite podcasts with AI-powered features
The Stem Cell Podcast
Ep. 8: Aged Neurons in a Dish Featuring Justine Miller
Dec 13, 2013
Justine Miller, a PhD candidate from Lorenz Studer's lab at Memorial Sloan Kettering, discusses her groundbreaking research on aging neurons derived from stem cells. She reveals how they age in culture, shedding light on neurodegeneration and the challenges in modeling such diseases. The conversation touches on innovative gene editing techniques like CRISPR and the implications of recent findings on male birth control. Join them as they explore the intersection of neuroscience, aging, and cutting-edge research methodologies.
01:07:19
Episode guests
AI Summary
AI Chapters
Episode notes
Podcast summary created with Snipd AI
Quick takeaways
- The research highlights the role of progerin in creating aged neurons, aiding the understanding of age-related neurological disorders like Parkinson's.
- Recent discoveries in developing a 'ground state' for embryonic stem cells have significant implications for creating mature cell types for therapies.
Deep dives
Introduction to Progerin and Aging Research
The podcast emphasizes the significance of progerin, a protein linked to premature aging, in modeling age-related neurological disorders. Researchers are exploring how overexpression of progerin can mimic the aging process in neurons, allowing them to potentially better understand diseases like Parkinson's that affect older populations. This approach addresses the challenge faced by scientists in studying late-onset diseases using pluripotent stem cells, which may not accurately represent the disease phenotype due to their youthful characteristics. By inducing an aging-like state in human neurons, they hope to uncover critical biological insights for developing effective therapies.
Get the Snipd
podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered
Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any
moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share
& Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered
podcast player
Listen to all your favourite podcasts with AI-powered features
Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode