Ep. 8: Aged Neurons in a Dish Featuring Justine Miller
The Stem Cell Podcast
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Modeling Neurodegeneration: Challenges and Innovations
This chapter explores the complexities of using pluripotent stem cells to model late-onset neurodegenerative diseases, specifically Parkinson's disease. It discusses the limitations of current modeling techniques in reflecting age-related diseases and introduces innovative approaches like progerin to induce aging characteristics in cells. The chapter also highlights intriguing findings on neuronal aging, the challenges of defining aged cells, and the potential for drug screening using these methodologies.
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