Episode 412: Metformin and the MeMeMe Study: Is It Time?
Feb 11, 2025
auto_awesome
Explore the promising role of metformin in cancer prevention and diabetes management, highlighted by recent studies including the intriguing MeMeMe trial. Discover how statins may cut dementia risk, and learn about omega-3s' impact on aging. The podcast also dives into the hidden dangers of juicing, microplastics affecting brain health, and the importance of menopause for artery health. Plus, hear about luteolin's surprising benefits for dark hair, and the advantages of telemedicine for heart patients with diabetes.
Metformin shows promise not only for diabetes management but also in reducing cancer risk and promoting longevity, especially when combined with a Mediterranean diet.
Recent studies reveal that statins, particularly rosuvastatin, significantly lower dementia risk, highlighting their potential benefits beyond cholesterol management.
Deep dives
Statins and Dementia Risk
Statins have been shown to reduce dementia risk according to a comprehensive study involving 7 million patients. The analysis revealed that statin use lowered the risk of developing any form of dementia by 14%, with varying reductions in specific types such as Alzheimer’s and vascular dementia. Specifically, rosuvastatin demonstrated a notable 28% decrease in all-cause dementia risk. Additionally, prolonged use of statins, particularly over three years, correlated with an astonishing 63% reduction in dementia risk, challenging the common fear surrounding their usage.
Omega-3 and Biological Aging
A recent study highlighted the significant effects of omega-3 supplementation, combined with vitamin D and exercise, on biological aging in older adults. Participants showed slowed biological aging markers over a three-year period, indicating that omega-3, even at standard doses, could play a vital role in longevity. Interestingly, the results revealed that those actively taking omega-3 and engaging in regular home exercise experienced the most substantial benefits, outpacing other combinations of interventions. This underscores the importance of omega-3 as an essential component of a healthy aging strategy.
Metformin as an Anti-Aging Agent
Metformin has garnered attention for its potential anti-aging effects, particularly in non-diabetic individuals, as suggested by multiple studies over the years. Research indicates that metformin not only helps manage blood sugar but also may lower the risk of various cancers significantly, including pancreatic cancer. Moreover, one major trial demonstrated promising results where participants adhering to a Mediterranean diet alongside metformin reported a greatly reduced incidence of metabolic syndrome. This growing body of evidence suggests that metformin could play a crucial role in longevity and overall health maintenance.
This week, he takes a deep dive into the potential role of metformin as a drug for cancer prevention, diabetes management, and anti-aging, reporting on several new studies, including the MeMeMe randomized trial. The data is compelling.
He also discusses several key topics, including a new study on statins reducing dementia risk, Omega-3’s role in slowing aging, the hidden harms of juicing, microplastics in the brain, menopause and artery health, luteolin for dark hair, and the impact of telemedicine coaching on diabetic heart patients.
Get the Snipd podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share & Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode