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Varroa destructor mites are significantly responsible for the alarming decline in honeybee populations, with annual losses ranging from one-third to half of all colonies in the United States. These parasites invade honeybees, feeding on their fat body, which plays a critical role in nutrient storage, metabolism regulation, and immune function. The presence of these mites not only compromises the health of individual bees but also increases their vulnerability to pesticides and pathogens, exacerbating the multifaceted challenges faced by bee populations. The intricate connection between mitosis and colony health illustrates the urgent need for innovative solutions to manage or eradicate these pests.