Immune Booster #3: NKT cells and cancer, and DEI in research with Tonya Webb
Jul 16, 2024
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Tonya Webb, a Professor at the University of Maryland School of Medicine, dives into the fascinating world of NKT cells and their role in cancer research. She shares innovative strategies for activating these cells to combat ovarian cancer and enhance vaccine efficacy. Tonya emphasizes the importance of diversity, equity, and inclusion in STEM, revealing how varied backgrounds drive innovation and improve patient outcomes. Her insights on mentoring underrepresented students and community initiatives further underscore the need for representation in scientific fields.
The podcast discusses the pivotal role of NKT cells in cancer, highlighting their potential for tumor regression and immune evasion strategies.
Tonya Webb emphasizes the critical need for diversity, equity, and inclusion in research to foster innovation and mentorship in STEM fields.
Deep dives
Journey into Immunology
The speaker reflects on their early passion for science, tracing it back to an interest sparked during their undergraduate studies, where they pursued biology, chemistry, psychology, and Spanish. A pivotal moment occurred at a career fair when a recruiter suggested they explore research, leading to a transformative internship focused on HIV vaccine development. This experience ignited a love for research, prompting further exploration of immunology during graduate studies, where they wrestled with complex concepts like immunoglobulins and NKT cells. Ultimately, their academic journey underscored the importance of curiosity and mentorship in navigating the sciences.
Research on NKT Cells
The discussion highlights the intriguing role of NKT cells in immune responses, particularly how they recognize lipid antigens via CD1D molecules. Research carried out during their postdoctoral fellowship delved into the mechanisms of immune evasion by viruses and their implications for cancer immunotherapy. The development of artificial cells designed to activate NKT cells showcases innovative approaches to potential vaccine strategies and cancer treatments. This research aims to uncover how NKT cells can mediate tumor regression, revealing their duality in both attacking cancer cells and being suppressed by them.
Commitment to Diversity in STEM
The speaker emphasizes the significance of diversity within the scientific community, advocating for varied backgrounds and perspectives to enrich research and foster innovation. They actively engage in initiatives aimed at increasing representation in STEM, including mentorship programs for undergraduates and high school students interested in cancer research. Their own experiences reflect the influence of mentors in shaping their career, and they are now committed to providing similar guidance to the next generation. By promoting inclusivity and awareness in research settings, the speaker hopes to inspire impactful changes in both science and community health.
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Tonya Webb to talk about her career, the role of NKT cells in cancer, and her efforts to ensure diversity, equity, and inclusion in research.