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Chest Pain and Pathophysiology
- Unstable angina has two main presentations: new/worsening angina and angina at rest.
- These correlate with different pathophysiologies: progressive plaque growth vs. plaque rupture.
Predictability of Angina Types
- Progressive angina is more predictable than angina at rest due to plaque rupture's unpredictability.
- Plaque rupture can lead to sudden, complete thrombotic occlusion and STEMI.
Correlation of Symptoms and Pathophysiology
- Braunwald's classifications correlate with clinical findings: plaque rupture is twice as common and has higher troponin positivity.
- This supports the idea that symptoms and pathophysiology are linked.