Renin Angiotensin System Blockade in Persons with Advanced Chronic Kidney Disease

Mark Sarnak, Chief of Nephrology at Tufts School of Medicine, dives deep into the role of renin-angiotensin system blockade in advanced chronic kidney disease. He discusses the complexities and risks associated with using ACE inhibitors and ARBs, particularly hyperkalemia and acute kidney injury. Highlighting meta-analyses, he reveals significant reductions in kidney failure events with these treatments. The conversation also covers new insights into potassium management and the promising role of SGLT2 inhibitors, capturing the optimism in nephrology communities.