#1040 Luana Colloca: Placebo Effects Through the Lens of Translational Research

Jan 2, 2025

Luana Colloca, a leading expert in pain and translational symptom science, discusses the intriguing world of placebos. She explains how placebos function in clinical settings and the role of expectations and culture. The conversation delves into genetic influences on the placebo effect, particularly regarding alcohol use disorder. Colloca emphasizes the importance of enhancing clinical trials and patient communication, shedding light on how these elements can improve therapeutic outcomes in healthcare.

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INSIGHT

Placebo's Importance in Research

Placebo research is crucial because many clinical trials fail when active drugs don't outperform placebos.
Placebo effects can be as strong as, or even stronger than, some treatments.

INSIGHT

Improving Clinical Trials with Placebo Science

Placebo science can improve clinical trial design by examining expectations, omics, and individual responses.
This includes understanding both placebo and nocebo effects.

INSIGHT

Goals of the Placebo Effects Book

The book "Placebo Effects" aims to make placebo research accessible to everyone, including the public.
It also integrates interdisciplinary perspectives, from cultural influences to digital therapeutics.

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Dr. Luana Colloca is Professor in Pain and Translational Symptom Science, Director of the Placebo Beyond Opinions Center, MPower Professor, and Adjunct Professor in the Department of Anesthesiology (School of Medicine) at the University of Maryland, Baltimore. She is co-editor of Placebo Effects Through the Lens of Translational Research.

In this episode, we focus on Placebo Effects Through the Lens of Translational Research. We start by discussing what a placebo is, how placebos work, and the goals of the book. We talk about placebo-based clinical interventions, expectations and culture in a clinical context, individual variation in the placebo effect, and we explore the example of the placebo effect in alcohol use disorder. We discuss when a placebo effect becomes a treatment effect, the patient-clinician relationship, and whether psychotherapy is an open-label placebo. Finally, we discuss why placebos matter for research quality.

A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: PER HELGE LARSEN, JERRY MULLER, BERNARDO SEIXAS, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, FILIP FORS CONNOLLY, ROBERT WINDHAGER, RUI INACIO, ZOOP, MARCO NEVES, COLIN HOLBROOK, PHIL KAVANAGH, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, FERGAL CUSSEN, HAL HERZOG, NUNO MACHADO, JONATHAN LEIBRANT, JOÃO LINHARES, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, ROMAIN ROCH, DIEGO LONDOÑO CORREA, YANICK PUNTER, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, NELLEKE BAK, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, EDWARD HALL, HEDIN BRØNNER, DOUGLAS FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, SCOTT, ZACHARY FISH, TIM DUFFY, SUNNY SMITH, JON WISMAN, WILLIAM BUCKNER, PAUL-GEORGE ARNAUD, LUKE GLOWACKI, GEORGIOS THEOPHANOUS, CHRIS WILLIAMSON, PETER WOLOSZYN, DAVID WILLIAMS, DIOGO COSTA, ALEX CHAU, AMAURI MARTÍNEZ, CORALIE CHEVALLIER, BANGALORE ATHEISTS, LARRY D. LEE JR., OLD HERRINGBONE, MICHAEL BAILEY, DAN SPERBER, ROBERT GRESSIS, IGOR N, JEFF MCMAHAN, JAKE ZUEHL, BARNABAS RADICS, MARK CAMPBELL, TOMAS DAUBNER, LUKE NISSEN, KIMBERLY JOHNSON, JESSICA NOWICKI, LINDA BRANDIN, GEORGE CHORIATIS, VALENTIN STEINMANN, PER KRAULIS, ALEXANDER HUBBARD, BR, JONAS HERTNER, URSULA GOODENOUGH, DAVID PINSOF, SEAN NELSON, MIKE LAVIGNE, JOS KNECHT, LUCY, MANVIR SINGH, PETRA WEIMANN, CAROLA FEEST, MAURO JÚNIOR, 航豊川, TONY BARRETT, BENJAMIN GELBART, NIKOLAI VISHNEVSKY, STEVEN GANGESTAD, AND TED FARRIS!

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