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Neurology® Podcast

Frontotemporal Dementia Differential Diagnosis in Clinical Practice

Mar 13, 2025
Dr. Amy Brodtmann, director at the Eastern Cognitive Disorders Clinic and professor, joins to discuss the nuances of diagnosing frontotemporal dementia (FTD). She emphasizes the holistic approach needed in assessments, particularly regarding behavioral changes that may mask underlying conditions. The conversation delves into the complexities of distinguishing FTD from Alzheimer's disease and the potential for misdiagnosis. Brodtmann highlights the critical role of follow-up care and emerging blood biomarkers to enhance diagnostic accuracy, shedding light on an often-overlooked area in dementia care.
27:57

Episode guests

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Quick takeaways

  • Diagnosing frontotemporal dementia (FTD) requires a comprehensive evaluation of behavioral changes and psychiatric history to differentiate from other disorders.
  • The Cambridge Behavioral Inventory (CBI) aids in identifying FTD by assessing specific behavioral patterns, enriching the diagnostic process with informant insights.

Deep dives

Understanding Frontal Network Impairment Referrals

A review of referrals to the Eastern Cognitive Disorders Clinic over nine years revealed that a significant number of patients presented with frontal network impairment, which often raises the concern of frontotemporal dementia (FTD). Out of 611 total referrals, approximately 161 were related to frontal behavioral changes, with various diagnoses ultimately surfaced. Notably, only about a quarter of those referred with suspected FTD actually received a diagnosis of behavioral variant FTD, while nearly half were diagnosed with other forms of FTD or primary psychiatric disorders. This highlights the complexities of diagnosis, as behavioral changes can stem from various neurodegenerative and psychiatric conditions, necessitating a careful and comprehensive evaluation process to guide appropriate interventions.

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