Episode #188: Latest Insights on Mast Cell Activation Syndrome with Dr. Kelly McCann, MD and Beth O'Hara, FN
Aug 25, 2023
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Dr. Kelly McCann and Beth O'Hara discuss triggers for MCAS, connection between methylation and MCAS, role of chronic infections, exposure to gas stoves, immune modulation, and more. They explore salicylates, histamine intolerance, oxalates, benzodiazepines, and complex interventions for MCAS. The podcast also explores IV therapy, nutrient support, EMF exposure, daily health practices, and ends with personal appreciation and support.
Salicylates and oxalates in foods can trigger mast cells, contributing to inflammation.
Infections like Bartonella and Lyme can activate mast cells, linking infections to MCAS symptoms.
Exposure to environmental pollutants like gas stoves can worsen mast cell activation.
Histamine intolerance interventions involve quercetin use, with considerations for hormonal effects and microbiome impact.
Deep dives
Recognizing Mast Cell Activation Syndrome
Mast Cell Activation Syndrome (MCAS) can manifest with unexplained allergy symptoms, GI issues, brain fog, and chronic inflammation. Dr. Kelly McCann's journey with MCAS started due to her health struggles, leading to the recognition and understanding of this condition over time.
Impact of Infections on Mast Cell Activation
Infections like Bartonella and Lyme, along with COVID, can trigger mast cell activation syndrome. Treating these infections can lead to improvements in MCAS symptoms, emphasizing the connection between infections and mast cell dysregulation.
Salicylates, Oxalates, and Mast Cell Activation
Salicylates and oxalates, commonly found in various foods, can trigger mast cells, contributing to inflammation. Managing salicylate and oxalate intolerance can help alleviate mast cell activation symptoms, highlighting the impact of dietary components on mast cell reactivity.
Environmental Triggers and Mast Cell Activation
Exposure to environmental pollutants like natural gas leaks from stoves can exacerbate mast cell activation due to their toxicity. Recognizing and addressing these environmental triggers are crucial in managing mast cell activation syndrome and improving overall health.
Understanding Mast Cell Activation Syndrome and its Connection to Hypermobility Syndromes
Mast cell activation syndrome and its connection to hypermobility syndromes are explored. The buildup of toxic intermediates triggers mast cells leading to symptoms like extreme abdominal pain and visceral hypersensitivity. The connection between mast cell activation and Ehlers-Danlos syndrome is discussed, highlighting a bidirectional relationship where activated mast cells can impact structural integrity by tenderizing ligaments and tendons.
Exploring Interventions for Mast Cell Activation and Histamine Intolerance
Cutting-edge interventions for mast cell activation, especially related to histamine intolerance, are discussed. The efficacy of quercetin, commonly used for mast cell stabilization, is debated, with considerations for hormonal contributors. The use of low dose immunotherapy and the potential negative impact of excessive quercetin on the microbiome are also examined.
Innovative Approaches and Tools for Mast Cell Activation Syndrome
Various tools and medications beyond common discussions are explored for addressing mast cell activation. Peptides like PPC 157 and KPV, along with low dose immunotherapy, are considered helpful. The role of zinc, magnesium, and other minerals in managing mast cell activation syndrome is detailed, emphasizing the importance of individualized approaches.
In this episode, you will learn about the latest insights on Mast Cell Activation Syndrome.
About My Guests:
My guests for this episode are Dr. Kelly McCann, MD and Beth O'Hara, FN. Both of our guests today are prior podcast guests. You can find their full bios by looking at episode 142 for Dr. Kelly and episodes 101, 109, 122, and 156 for Beth. Dr. Kelly works with patients with complex, chronic illnesses and is also an experts in Mast Cell Activation Syndrome. Beth is an expert on Mast Cell Activation Syndrome and operates MastCell360.com. Both of them are amazing practitioners and are people that I have been honored to collaborate with and be mentored by. They recently partnered up to host the Mastering Mast Cell Activation Summit which runs in October.
Key Takeaways:
What are the triggers for more sensitive patients?
What are the top triggers of MCAS?
Is MCAS the core problem or a symptom of other root causes?
Can aggressive detoxification trigger mast cells?
What is the connection between methylation and MCAS?
What tests are consistently helpful for MCAS?
How might MCAS lead to neuro-cognitive symptoms or brain fog?
Can salicylates and oxalates trigger mast cells?
Are benzodiazepines helpful or do they complicate the picture?
Can exposure to gas stoves trigger mast cells?
What is the role of chronic infections in MCAS?
How do hypercoagulation and biofilms fit into the discussion on MCAS?
What place does immune modulation have in a MCAS strategy?
Can porphyria or pyroluria contribute to MCAS?
How might MCAS contribute to Ehlers-Danlos Syndrome?
What are the top treatments for stabilizing mast cells?
How might peptides, LDN, or black seed oil support the body?
The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.
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