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Degrees of Health

Dr Mark Tarnopolsky, MD, PhD | Mitochondrial Mastery: Supplements, Exercise & Longevity Insights

Jan 22, 2025
48:58

Dr. Mark Tarnopolsky is a world-renowned expert in mitochondrial health, muscle function, and ageing science. As a clinician-scientist at McMaster University, he has dedicated his career to understanding how we can optimise our mitochondria - the tiny powerhouses in our cells - for better energy, performance, and longevity.


This is for you if you’ve ever asked yourself: Why does energy fade as I age? How can I boost my endurance, strength, and resilience whatever age I am? And what are the best ways to support (even enhance) these powerhouses naturally?


We cover:

🔥 Mitochondria 101 - why they’re central to health, ageing, and energy production

🌟 Signs of mitochondrial dysfunction - fatigue, muscle loss, and cataracts

🏋️‍♀️ Exercise for mitochondria – Endurance vs. resistance training benefits (on mitochondrial mass and function)

💡 Mitochondrial Biogenesis - how to double your mitochondria in 3 months

🍎 Supplements demystified - the science on CoQ10, NAD precursors, beetroot extract, and urolithin A

🧠 Aging & oxidative stress - mitophagy and why antioxidants alone won’t cut it

🩺 Mark’s regimen - he practices what he preaches: the nutrition, supplements, and exercise strategies he uses to stay on top of his game (and hold a +68 VO2 max in his 60s)


What we do know? There’s no shortcut to better mitochondria. What we can do? We listen and we learn what Dr Mark describes to be the gold standard for optimising energy, longevity, and quality of life. Lace up your sneakers, team!


Find Dr Mark:

McMaster University

Supplement Brand - Stay Above Nutrition

Mark’s papers


Mentioned in this episode:

Antioxidants prevent health-promoting effects of physical exercise in humans

PubMed

Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health


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